A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions
نویسندگان
چکیده
منابع مشابه
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions.
The use of stable isotopes in conjunction with compartmental modeling analysis has greatly facilitated studies of the metabolism of the apolipoprotein B (apoB)-containing lipoproteins in humans. The aim of this study was to develop a multicompartment model that allows us to simultaneously determine the kinetics of apoB and triglyceride (TG) in VLDL(1) and VLDL(2) after a bolus injection of [(2)...
متن کاملREVISED R2 A New Combined Multicompartmental Model for Apolipoprotein B100 and Triglyceride Metabolism in VLDL Subfractions
The use of stable isotopes in conjunction with compartmental modeling analysis has greatly facilitated studies of the metabolism of the apoB-containing lipoproteins in humans. The aim of this study was to develop a multicompartment model that allows to simultaneously determine the kinetics of apoB and TG in VLDL1 and VLDL2 after a bolus injection of H3-leucine and H5glycerol, and to follow the ...
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To gain insight into the mechanisms regulating plasma lipid homeostasis, FFA, VLDL-triglyceride (TG), and VLDL-apolipoprotein B-100 (apoB-100) kinetics are commonly assessed using stable isotope-labeled tracer methods. The reproducibility of these measurements, which is critical for the experimental design, is unknown. Therefore, we investigated the repeatability of plasma FFA, VLDL-TG, and VLD...
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Apolipoprotein B (apoB) metabolism was investigated in 20 men with plasma triglyceride 0.66-2.40 mmol/l and plasma cholesterol 3.95-6. 95 mmol/l. Kinetics of VLDL(1) (S(f) 60-400), VLDL(2) (S(f) 20-60), IDL (S(f) 12-20), and LDL (S(f) 0;-12) apoB were analyzed using a trideuterated leucine tracer and a multicompartmental model which allowed input into each fraction. VLDL(1) apoB production vari...
متن کاملImpact of age on the metabolism of VLDL, IDL, and LDL apolipoprotein B-100 in men.
Levels of plasma very low density lipoprotein (VLDL) and low density lipoprotein (LDL) constituents increase with age. In an attempt to further define the mechanisms responsible for these changes, kinetic studies of VLDL and LDL apolipoprotein (apo) B-100 were carried out in 19 normolipidemic male subjects with plasma total cholesterol and triglyceride levels below the 90th percentile whose age...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2005
ISSN: 0022-2275
DOI: 10.1194/jlr.m400108-jlr200